HRD-negative high-grade carcinoma of the ovary in <i>BRCA2</i> pathogenic variant carrier

HRD-negative high-grade carcinoma of the ovary in <i>BRCA2</i> pathogenic variant carrier

Background. Homologous recombination deficiency (HRD) is a valuable molecular marker for predicting response to platinum agents and poly(ADP-ribose)-polymerase (PARP) inhibitors. Germline and somatic alterations in the BRCA1 and BRCA2 genes are the major cause of HRD in ovarian cancer. However, in s...

Full description

Saved in:
Bibliographic Details
Main Authors: A. P. Sokolenko, S. V. Poletaeva, A. D. Shestakova, T. V. Gorodnova, I. V. Berlev, E. N. Imyanitov
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2024-05-01
Series:Сибирский онкологический журнал
Subjects:
<i>brca1</i> and <i>brca2</i> mutations
loss of heterozygosity
brcaness
high-grade ovarian carcinoma
homologous recombination deficiency
Online Access:https://www.siboncoj.ru/jour/article/view/3050
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.siboncoj.ru/jour/article/view/3050

Similar Items