Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model
Inflammation is associated with an increased risk of developing various cancers in both animals and humans, primarily solid tumors but also myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Multi-walled carbon nanotubes (MWCNTs), a type of carbon...
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MDPI AG
2024-09-01
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| Online Access: | https://www.mdpi.com/2305-6304/12/9/646 |
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| author | Qingqing Wang Jingdan Han Mujia Wei Huikai Miao Min Zhang Biao Wu Yao Chen Yanwen Zheng Robert Peter Gale Bin Yin |
| author_facet | Qingqing Wang Jingdan Han Mujia Wei Huikai Miao Min Zhang Biao Wu Yao Chen Yanwen Zheng Robert Peter Gale Bin Yin |
| author_sort | Qingqing Wang |
| collection | DOAJ |
| description | Inflammation is associated with an increased risk of developing various cancers in both animals and humans, primarily solid tumors but also myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Multi-walled carbon nanotubes (MWCNTs), a type of carbon nanotubes (CNTs) increasingly used in medical research and other fields, are leading to a rising human exposure. Our study demonstrated that exposing mice to MWCNTs accelerated the progression of spontaneous MOL4070LTR virus-induced leukemia. Additionally, similar exposures elevated pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α and induced reactive oxygen species (ROS) in a murine macrophage cell line. These effects were significantly reduced in immunodeficient mice and when mice were treated with methoxypolyethylene glycol amine (PEG)-modified MWCNTs. These findings underscore the necessity of evaluating the safety of MWCNTs, particularly for those with hematologic cancers. |
| format | Article |
| id | doaj-art-1bc448f41851400f823276edc894125a |
| institution | Kabale University |
| issn | 2305-6304 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-1bc448f41851400f823276edc894125a2025-01-03T02:57:14ZengMDPI AGToxics2305-63042024-09-0112964610.3390/toxics12090646Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse ModelQingqing Wang0Jingdan Han1Mujia Wei2Huikai Miao3Min Zhang4Biao Wu5Yao Chen6Yanwen Zheng7Robert Peter Gale8Bin Yin9Clinical Medical Research Center, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi 214002, ChinaClinical Medical Research Center, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi 214002, ChinaClinical Medical Research Center, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi 214002, ChinaDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, ChinaDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, ChinaDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, ChinaDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, ChinaCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, ChinaHaematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UKClinical Medical Research Center, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi 214002, ChinaInflammation is associated with an increased risk of developing various cancers in both animals and humans, primarily solid tumors but also myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Multi-walled carbon nanotubes (MWCNTs), a type of carbon nanotubes (CNTs) increasingly used in medical research and other fields, are leading to a rising human exposure. Our study demonstrated that exposing mice to MWCNTs accelerated the progression of spontaneous MOL4070LTR virus-induced leukemia. Additionally, similar exposures elevated pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α and induced reactive oxygen species (ROS) in a murine macrophage cell line. These effects were significantly reduced in immunodeficient mice and when mice were treated with methoxypolyethylene glycol amine (PEG)-modified MWCNTs. These findings underscore the necessity of evaluating the safety of MWCNTs, particularly for those with hematologic cancers.https://www.mdpi.com/2305-6304/12/9/646multi-walled carbon nanotubesleukemiaPEGinflammationMOL4070LTR |
| spellingShingle | Qingqing Wang Jingdan Han Mujia Wei Huikai Miao Min Zhang Biao Wu Yao Chen Yanwen Zheng Robert Peter Gale Bin Yin Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model Toxics multi-walled carbon nanotubes leukemia PEG inflammation MOL4070LTR |
| title | Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model |
| title_full | Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model |
| title_fullStr | Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model |
| title_full_unstemmed | Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model |
| title_short | Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model |
| title_sort | multi walled carbon nanotubes accelerate leukaemia development in a mouse model |
| topic | multi-walled carbon nanotubes leukemia PEG inflammation MOL4070LTR |
| url | https://www.mdpi.com/2305-6304/12/9/646 |
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