Immortalized mammosphere-derived epithelial cells retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties

Immortalized mammosphere-derived epithelial cells retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties

Abstract Background The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and immunomodulatory properties in vitro, which warrants its study as a potential biologic treatment with the potential to be translated to human medi...

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Bibliographic Details
Main Authors: Nikola Danev, Julia M. Poggi, Emilie A. Dewever, Arianna P. Bartlett, Leane Oliveira, Lucas Huntimer, Rebecca M. Harman, Gerlinde R. Van de Walle
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Stem Cell Research & Therapy
Subjects:
Mammary epithelial cells
Secretome
Immortalization
Immunomodulation
Antimicrobial effects
Fibroblast migration
Online Access:https://doi.org/10.1186/s13287-024-04019-1
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https://doi.org/10.1186/s13287-024-04019-1

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