Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis

Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) requires innovative therapeutic strategies to counteract its progression and metastatic potential. Since the majority of patients are diagnosed with advanced metastatic disease, treatment strategies targeting not only the primary tumor but...

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Main Authors: Adrián Palencia-Campos, Laura Ruiz-Cañas, Marcelina Abal-Sanisidro, Juan Carlos López-Gil, Sandra Batres-Ramos, Sofia Mendes Saraiva, Balbino Yagüe, Diego Navarro, Sonia Alcalá, Juan A. Rubiolo, Nadège Bidan, Laura Sánchez, Simona Mura, Patrick C. Hermann, María de la Fuente, Bruno Sainz
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Pancreatic ductal adenocarcinoma
Tumor-associated macrophages
Tumor microenvironment
Lipid nanoemulsions
Galunisertib
Liver metastasis
Online Access:https://doi.org/10.1186/s12951-024-03010-5
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https://doi.org/10.1186/s12951-024-03010-5

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