Leveraging the enrichment analysis from a genome-wide association study against epilepsy—focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epilepsy

Leveraging the enrichment analysis from a genome-wide association study against epilepsy—focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epilepsy

BackgroundDrug-resistant epilepsy (DRE) is a chronic neurological disorder with somatic impacts and an increased risk of psychiatric comorbidities and cognitive impairment. Previous studies suggested that genomic variants could contribute to the high interindividual variability in epilepsy and in it...

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Main Authors: Alice Y. W. Chang, Chin-Wei Huang, Ping-Lin Tsai, Chun-An Liang, Wei Chen Liao, Tzu-Fun Fu, Hui Hua Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Nutrition
Subjects:
epilepsy
drug-resistant epilepsy
genome-wide association study
pharmacogenomics
tryptophan catabolites
multivitamin supplementation
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1539145/full
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