Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy

Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy

BackgroundIgA nephropathy (IgAN) is a leading cause of renal failure, but its pathogenesis remains unclear, complicating diagnosis and treatment. The invasive nature of renal biopsy highlights the need for non-invasive diagnostic biomarkers. Bulk RNA sequencing (RNA-seq) of urine offers a promising...

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Bibliographic Details
Main Authors: Boji Xie, Shuting Pang, Yuli Xie, Qiuyan Tan, Shanshan Li, Mujia Jili, Yian Huang, Binran Zhao, Hao Yuan, Junhao Mi, Xuesong Chen, Liangping Ruan, Hong Chen, Xiaolai Li, Boning Hu, Jing Huang, Rirong Yang, Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Genetics
Subjects:
IgA nephropathy
urine bulk RNA sequencing
non-invasive biomarkers
TYROBP
HCK
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1516513/full
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https://www.frontiersin.org/articles/10.3389/fgene.2024.1516513/full

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