Evaluation of Bridge Capture technology for mutation profiling in liquid biopsies of metastatic colorectal cancer patients

Evaluation of Bridge Capture technology for mutation profiling in liquid biopsies of metastatic colorectal cancer patients

Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, often presenting at an advanced stage with significant molecular heterogeneity. This is the first study to evaluate the performance of a novel next-generation sequencing (NGS)-based Bridge Capture technology for m...

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Main Authors: Aparna Ganesan, Anttoni Korkiakoski, Simona Adamusová, Anna Musku, Tuula Rantasalo, Nea Laine, Emma Andersson, Emerik Osterlund, Ali Ovissi, Päivi Halonen, Tatu Hirvonen, Jorma Kim, Jukka Laine, Antti Silvoniemi, Heikki Minn, Juuso Blomster, Anna-Kaisa Anttonen, Soili Kytölä, Pia Osterlund, Juha-Pekka Pursiheimo, Pirjo Nummela, Manu Tamminen, Ari Ristimäki
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Bridge Capture
Colorectal cancer
cfDNA
ctDNA
ddPCR
NGS
Online Access:https://doi.org/10.1038/s41598-025-04827-2
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https://doi.org/10.1038/s41598-025-04827-2

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