Allostery in homodimeric SARS-CoV-2 main protease

Allostery in homodimeric SARS-CoV-2 main protease

Abstract Many enzymes work as homodimers with two distant catalytic sites, but the reason for this choice is often not clear. For the main protease Mpro of SARS-CoV-2, dimerization is essential for function and plays a regulatory role during the coronaviral replication process. Here, to analyze a po...

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Main Authors: Emanuele Fornasier, Simone Fabbian, Haidi Shehi, Janine Enderle, Barbara Gatto, Daniele Volpin, Barbara Biondi, Massimo Bellanda, Gabriele Giachin, Alice Sosic, Roberto Battistutta
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07138-w
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https://doi.org/10.1038/s42003-024-07138-w

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