Signal peptidase SpsB coordinates staphylococcal cell cycle, surface protein septal trafficking, and LTA synthesis

ABSTRACT Cell wall-anchored surface proteins of Gram-positive bacteria, harboring a highly conserved YSIRK/G-S signal peptide (SPYSIRK+), are deposited at cell division septum and anchored to septal peptidoglycan. The mechanisms supporting YSIRK protein septal trafficking remain elusive. Previously,...

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Bibliographic Details
Main Authors: Ran Zhang, Yaosheng Jia, Salvatore J. Scaffidi, Jesper J. Madsen, Wenqi Yu
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
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Online Access:https://journals.asm.org/doi/10.1128/mbio.02673-24
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