Effects of dopamine β‐hydroxylase inhibition in pressure overload‐induced right ventricular failure

Effects of dopamine β‐hydroxylase inhibition in pressure overload‐induced right ventricular failure

Abstract Activation of the sympathetic nervous system is observed in pulmonary arterial hypertension patients. This study investigates whether inhibiting the conversion of dopamine into noradrenaline by dopamine β‐hydroxylase (DβH) inhibition with BIA 21‐5337 improved right ventricular (RV) function...

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Main Authors: Stine Andersen, Julie Sørensen Axelsen, Anders H. Nielsen‐Kudsk, Janne Schwab, Caroline D. Jensen, Steffen Ringgaard, Asger Andersen, Rowan Smal, Aida Llucià‐Valldeperas, Frances Handoko de Man, Bruno Igreja, Nuno Pires
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Pulmonary Circulation
Subjects:
animal study
dopamine β‐hydroxylase
noradrenaline
right heart failure
sympathetic nervous system
Online Access:https://doi.org/10.1002/pul2.70008
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https://doi.org/10.1002/pul2.70008

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