Spontaneous Splenic Rupture in Melanoma
Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/865453 |
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| author | Hadi Mirfazaelian Ahmad Oryan Aida Davari Khosrow Daneshbod Yahya Daneshbod |
| author_facet | Hadi Mirfazaelian Ahmad Oryan Aida Davari Khosrow Daneshbod Yahya Daneshbod |
| author_sort | Hadi Mirfazaelian |
| collection | DOAJ |
| description | Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild splenomegaly with moderate free fluid in abdominopelvic cavity. Considering acute abdominal pain and hemodynamic instability, he underwent splenectomy with splenic rupture as the source of bleeding. Histologic examination showed diffuse infiltration by tumor. Immunohistochemical study (positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin) confirmed metastatic malignant melanoma. On further questioning, there was a past history of a nasal dark skin lesion which was removed two years ago with no pathologic examination. Spontaneous (nontraumatic) rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Metastasis of malignant melanoma is one of the rare causes of the spontaneous rupture of spleen. |
| format | Article |
| id | doaj-art-1a3c8bf6b83a41c7ad7edb8f465f7a16 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-1a3c8bf6b83a41c7ad7edb8f465f7a162025-08-20T03:54:21ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/865453865453Spontaneous Splenic Rupture in MelanomaHadi Mirfazaelian0Ahmad Oryan1Aida Davari2Khosrow Daneshbod3Yahya Daneshbod4Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, IranDr. Daneshbod Pathology Laboratory, Department of Pathology, Shiraz, IranDr. Daneshbod Pathology Laboratory, Department of Pathology, Shiraz, IranSpontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild splenomegaly with moderate free fluid in abdominopelvic cavity. Considering acute abdominal pain and hemodynamic instability, he underwent splenectomy with splenic rupture as the source of bleeding. Histologic examination showed diffuse infiltration by tumor. Immunohistochemical study (positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin) confirmed metastatic malignant melanoma. On further questioning, there was a past history of a nasal dark skin lesion which was removed two years ago with no pathologic examination. Spontaneous (nontraumatic) rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Metastasis of malignant melanoma is one of the rare causes of the spontaneous rupture of spleen.http://dx.doi.org/10.1155/2014/865453 |
| spellingShingle | Hadi Mirfazaelian Ahmad Oryan Aida Davari Khosrow Daneshbod Yahya Daneshbod Spontaneous Splenic Rupture in Melanoma Case Reports in Pathology |
| title | Spontaneous Splenic Rupture in Melanoma |
| title_full | Spontaneous Splenic Rupture in Melanoma |
| title_fullStr | Spontaneous Splenic Rupture in Melanoma |
| title_full_unstemmed | Spontaneous Splenic Rupture in Melanoma |
| title_short | Spontaneous Splenic Rupture in Melanoma |
| title_sort | spontaneous splenic rupture in melanoma |
| url | http://dx.doi.org/10.1155/2014/865453 |
| work_keys_str_mv | AT hadimirfazaelian spontaneoussplenicruptureinmelanoma AT ahmadoryan spontaneoussplenicruptureinmelanoma AT aidadavari spontaneoussplenicruptureinmelanoma AT khosrowdaneshbod spontaneoussplenicruptureinmelanoma AT yahyadaneshbod spontaneoussplenicruptureinmelanoma |