YY1 downregulation underlies therapeutic response to molecular targeted agents

YY1 downregulation underlies therapeutic response to molecular targeted agents

Abstract During targeted treatment, oncogene-addicted tumor cells often evolve from an initial drug-sensitive state through a drug-tolerant persister bottleneck toward the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory has not...

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Main Authors: Shichao Zhou, Jingyu Zang, Mei-Chun Cai, Kaiyan Ye, Jin Liu, Pengfei Ma, Jie Wu, Chenyang Dai, Haijiao Lu, Qing Zhang, Junhong Jiang, Tianqing Chu, Ying Shen, Li Tan, Guanglei Zhuang, Xiaojing Zhao, Lan Wang, Yu Zhuang, Yujie Fu
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07239-8
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https://doi.org/10.1038/s41419-024-07239-8

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