Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

Background: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a prolonged latent period, even after cessation of expos...

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Bibliographic Details
Main Authors: Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara
Format: Article
Language:English
Published: Komiyama Printing Co. Ltd 2024-12-01
Series:Environmental Health and Preventive Medicine
Subjects:
arsenic
cellular senescence
sasp
cancer
liver
hepatocellular carcinoma
gene expression
environment
Online Access:https://www.jstage.jst.go.jp/article/ehpm/29/0/29_24-00139/_html/-char/en
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https://www.jstage.jst.go.jp/article/ehpm/29/0/29_24-00139/_html/-char/en

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