Quantification of Amlodipine Maleate Content in Amorphous Solid Dispersions Produced by Fluidized Bed Granulation Using Process Analytical Technology Tools

Quantification of Amlodipine Maleate Content in Amorphous Solid Dispersions Produced by Fluidized Bed Granulation Using Process Analytical Technology Tools

<b>Background:</b> Active pharmaceutical ingredient (API) content is a critical quality attribute (CQA) of amorphous solid dispersions (ASDs) prepared by spraying a solution of APIs and polymers onto the excipients in fluid bed granulator. This study presents four methods for quantifying...

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Bibliographic Details
Main Authors: Sandi Svetič, Laura Medved, Klemen Korasa, Franc Vrečer
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion
process analytical technology
near-infrared spectroscopy
Raman spectroscopy
fluidized bed granulation
multivariate analysis
Online Access:https://www.mdpi.com/1999-4923/16/12/1538
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