Differential neuronal functions of LNX1 and LNX2 revealed by behavioural analysis in single and double knockout mice

Abstract Background Ligand of NUMB protein-X 1 (LNX1) and LNX2 proteins are closely related PDZ domain-containing E3 ubiquitin ligases that interact with and potentially modulate numerous synaptic and neurodevelopmentally important proteins. While both LNX1 and LNX2 are expressed in neurons, it is n...

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Bibliographic Details
Main Authors: Laura Cioccarelli, Joan A. Lenihan, Leah G. Erwin, Paul W. Young
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Behavioral and Brain Functions
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Online Access:https://doi.org/10.1186/s12993-025-00276-z
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