Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects
Abstract Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. Notably, cancer-a...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Biomedical Science |
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| Online Access: | https://doi.org/10.1186/s12929-024-01099-2 |
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| author | Zhipeng Cao Sadia Quazi Sakshi Arora Laura D. Osellame Ingrid J. Burvenich Peter W. Janes Andrew M. Scott |
| author_facet | Zhipeng Cao Sadia Quazi Sakshi Arora Laura D. Osellame Ingrid J. Burvenich Peter W. Janes Andrew M. Scott |
| author_sort | Zhipeng Cao |
| collection | DOAJ |
| description | Abstract Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. Notably, cancer-associated fibroblasts (CAFs) have emerged as one of the primary contributors in shaping TME, creating a favourable environment for cancer development. Many preclinical studies have identified promising targets on CAFs, demonstrating remarkable efficacy of some CAF-targeted treatments in preclinical models. Encouraged by these compelling findings, therapeutic strategies have now advanced into clinical evaluation. We aim to provide a comprehensive review of relevant subjects on CAFs, including CAF-related markers and targets, their multifaceted roles, and current landscape of ongoing clinical trials. This knowledge can guide future research on CAFs and advocate for clinical investigations targeting CAFs. |
| format | Article |
| id | doaj-art-19d4aa6c00b34fbb86bbb150874c8332 |
| institution | Kabale University |
| issn | 1423-0127 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj-art-19d4aa6c00b34fbb86bbb150874c83322025-01-12T12:34:07ZengBMCJournal of Biomedical Science1423-01272025-01-0132113510.1186/s12929-024-01099-2Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospectsZhipeng Cao0Sadia Quazi1Sakshi Arora2Laura D. Osellame3Ingrid J. Burvenich4Peter W. Janes5Andrew M. Scott6Tumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteTumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteTumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteTumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteTumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteTumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteTumour Targeting Laboratory, Olivia Newton-John Cancer Research InstituteAbstract Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. Notably, cancer-associated fibroblasts (CAFs) have emerged as one of the primary contributors in shaping TME, creating a favourable environment for cancer development. Many preclinical studies have identified promising targets on CAFs, demonstrating remarkable efficacy of some CAF-targeted treatments in preclinical models. Encouraged by these compelling findings, therapeutic strategies have now advanced into clinical evaluation. We aim to provide a comprehensive review of relevant subjects on CAFs, including CAF-related markers and targets, their multifaceted roles, and current landscape of ongoing clinical trials. This knowledge can guide future research on CAFs and advocate for clinical investigations targeting CAFs.https://doi.org/10.1186/s12929-024-01099-2Tumour microenvironmentCancer-associated fibroblastsTumour stromaTargeted therapyClinical trials |
| spellingShingle | Zhipeng Cao Sadia Quazi Sakshi Arora Laura D. Osellame Ingrid J. Burvenich Peter W. Janes Andrew M. Scott Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects Journal of Biomedical Science Tumour microenvironment Cancer-associated fibroblasts Tumour stroma Targeted therapy Clinical trials |
| title | Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects |
| title_full | Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects |
| title_fullStr | Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects |
| title_full_unstemmed | Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects |
| title_short | Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects |
| title_sort | cancer associated fibroblasts as therapeutic targets for cancer advances challenges and future prospects |
| topic | Tumour microenvironment Cancer-associated fibroblasts Tumour stroma Targeted therapy Clinical trials |
| url | https://doi.org/10.1186/s12929-024-01099-2 |
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