Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes

Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes

BackgroundThe prevalence of autism spectrum disorder (ASD) has significantly risen in the past three decades, prompting researchers to explore the potential contributions of environmental factors during pregnancy to ASD development. One such factor of interest is gestational hypothyroxinemia (HTX),...

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Main Authors: Enrique González-Madrid, Ma. Andreina Rangel-Ramírez, María C. Opazo, Luis Méndez, Karen Bohmwald, Susan M. Bueno, Pablo A. González, Alexis M. Kalergis, Claudia A. Riedel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Endocrinology
Subjects:
prenatal thyroid function
gestational hypothyroxinemia
neurodevelopment
autism spectrum disorder
behavior
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1381180/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1381180/full

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