Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice

Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice

Abstract Background L-DOPA has been considered the first-line therapy for treating Parkinson’s disease (PD) via restoring striatal dopamine (DA) to normalize the activity of local spiny projection neurons (SPNs) in the direct (dSPNs) pathway and the indirect (iSPNs) pathway. While the changes in str...

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Bibliographic Details
Main Authors: Hongxia Li, Ziluo Chen, Yuyan Tan, Huoqing Luo, Chen Lu, Chao Gao, Xin Shen, Fang Cai, Ji Hu, Shengdi Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell & Bioscience
Subjects:
Acetylcholine
Dopamine
Striatum
Parkinson’s disease
In vivo
Online Access:https://doi.org/10.1186/s13578-024-01328-z
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