Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury

Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury

Abstract Chronic complete spinal cord injury (SCI) is difficult to treat because of scar formation and cavitary lesions. While human iPS cell-derived neural stem/progenitor cell (hNS/PC) therapy shows promise, its efficacy is limited without the structural support needed to address cavitary lesions....

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Main Authors: Keitaro Ito, Munehisa Shinozaki, Shogo Hashimoto, Yusuke Saijo, Yu Suematsu, Tomoharu Tanaka, Kotaro Nishi, Hiroshi Yagi, Shinsuke Shibata, Yuko Kitagawa, Masaya Nakamura, Hideyuki Okano, Jun Kohyama, Narihito Nagoshi
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Spinal cord injury
Chronic phase
Cell transplantation
Scar resection
Scaffold
Online Access:https://doi.org/10.1038/s41598-024-82959-7
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https://doi.org/10.1038/s41598-024-82959-7

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