The therapeutic potential of RNA m(6)A in lung cancer
Abstract Lung cancer (LC) is a highly malignant and metastatic form of cancer. The global incidence of and mortality from LC is steadily increasing; the mean 5-year overall survival (OS) rate for LC is less than 20%. This frustrating situation may be attributed to the fact that the pathogenesis of L...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-024-01980-5 |
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| author | Jingran Yu Wei Sun Xiangxuan Zhao Yingying Chen |
| author_facet | Jingran Yu Wei Sun Xiangxuan Zhao Yingying Chen |
| author_sort | Jingran Yu |
| collection | DOAJ |
| description | Abstract Lung cancer (LC) is a highly malignant and metastatic form of cancer. The global incidence of and mortality from LC is steadily increasing; the mean 5-year overall survival (OS) rate for LC is less than 20%. This frustrating situation may be attributed to the fact that the pathogenesis of LC remains poorly understood and there is still no cure for mid to advanced LC. Methylation at the N6-position of adenosine (N6mA) of RNA (m(6)A) is widely present in human tissues and organs, and has been found to be necessary for cell development and maintenance of homeostasis. However, numerous basic and clinical studies have demonstrated that RNA m(6)A is deregulated in many human malignancies including LC. This can drive LC malignant characteristics such as proliferation, stemness, invasion, epithelial-mesenchymal transition (EMT), metastasis, and therapeutic resistance. Intriguingly, an increasing number of studies have also shown that eliminating RNA m(6)A dysfunction can exert significant anti-cancer effects on LC such as suppression of cell proliferation and viability, induction of cell death, and reversal of treatment insensitivity. The current review comprehensively discusses the therapeutic potential of RNA m(6)A and its underlying molecular mechanisms in LC, providing useful information for the development of novel LC treatment strategies. |
| format | Article |
| id | doaj-art-190a65d2d7e3466dafc50c57fe95c3bc |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-190a65d2d7e3466dafc50c57fe95c3bc2025-01-05T12:41:41ZengBMCCell Communication and Signaling1478-811X2024-12-0122114210.1186/s12964-024-01980-5The therapeutic potential of RNA m(6)A in lung cancerJingran Yu0Wei Sun1Xiangxuan Zhao2Yingying Chen3Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical UniversityDepartment of Radiology, Shengjing Hospital of China Medical UniversityCenter for Innovative Engineering Technology in Traditional Chinese Medicine, Liaoning University of Traditional Chinese MedicineDepartment of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical UniversityAbstract Lung cancer (LC) is a highly malignant and metastatic form of cancer. The global incidence of and mortality from LC is steadily increasing; the mean 5-year overall survival (OS) rate for LC is less than 20%. This frustrating situation may be attributed to the fact that the pathogenesis of LC remains poorly understood and there is still no cure for mid to advanced LC. Methylation at the N6-position of adenosine (N6mA) of RNA (m(6)A) is widely present in human tissues and organs, and has been found to be necessary for cell development and maintenance of homeostasis. However, numerous basic and clinical studies have demonstrated that RNA m(6)A is deregulated in many human malignancies including LC. This can drive LC malignant characteristics such as proliferation, stemness, invasion, epithelial-mesenchymal transition (EMT), metastasis, and therapeutic resistance. Intriguingly, an increasing number of studies have also shown that eliminating RNA m(6)A dysfunction can exert significant anti-cancer effects on LC such as suppression of cell proliferation and viability, induction of cell death, and reversal of treatment insensitivity. The current review comprehensively discusses the therapeutic potential of RNA m(6)A and its underlying molecular mechanisms in LC, providing useful information for the development of novel LC treatment strategies.https://doi.org/10.1186/s12964-024-01980-5Lung cancerM(6)AEpigeneticsTarget therapyTumorigenesis |
| spellingShingle | Jingran Yu Wei Sun Xiangxuan Zhao Yingying Chen The therapeutic potential of RNA m(6)A in lung cancer Cell Communication and Signaling Lung cancer M(6)A Epigenetics Target therapy Tumorigenesis |
| title | The therapeutic potential of RNA m(6)A in lung cancer |
| title_full | The therapeutic potential of RNA m(6)A in lung cancer |
| title_fullStr | The therapeutic potential of RNA m(6)A in lung cancer |
| title_full_unstemmed | The therapeutic potential of RNA m(6)A in lung cancer |
| title_short | The therapeutic potential of RNA m(6)A in lung cancer |
| title_sort | therapeutic potential of rna m 6 a in lung cancer |
| topic | Lung cancer M(6)A Epigenetics Target therapy Tumorigenesis |
| url | https://doi.org/10.1186/s12964-024-01980-5 |
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