A 3D culture model facilitates mass production of in vitro Plasmodium falciparum haemolymph-like sporozoites

A 3D culture model facilitates mass production of in vitro Plasmodium falciparum haemolymph-like sporozoites

Abstract Background The in vitro cultivation of individual stages of the Plasmodium falciparum mosquito life cycle is notably challenging. The main difficulty is replicating the intricate nutrient and metabolite exchanges necessary for oocyst development and sporozoite (SPZ) formation in the three-d...

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Bibliographic Details
Main Authors: Kiara Hatzakis, Zachary MacMillen, Payton Kirtley, Maya Aleshnick, Thomas Martinson, Priya Gupta, Kristian E. Swearingen, Brandon K. Wilder, James W. Davie, Marion Avril
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Ookinete
3D matrix
Scaffold
In vitro sporozoites
Online Access:https://doi.org/10.1186/s12936-025-05471-x
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https://doi.org/10.1186/s12936-025-05471-x

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