Extending gene set variation analysis with a reference dataset to stabilize scores

Extending gene set variation analysis with a reference dataset to stabilize scores

Abstract Background Biological pathways are sets of genes that jointly drive biological processes. Rather than analyzing genes individually, it is common practice to summarize sets of related genes using gene set variation analysis (GSVA). In short, GSVA summarizes a set of genes into a single score...

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Bibliographic Details
Main Authors: Lorin Towle-Miller, William Jordan, Alexandre Lockhart, Johannes Freudenburg, Aman Virmani, Mandy Bergquist, Jeffrey Miecznikowski, Will Powley
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Genomics
Subjects:
Gene signatures
Sequencing
Pathway analysis
Bayesian analysis
Online Access:https://doi.org/10.1186/s12864-025-11769-6
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https://doi.org/10.1186/s12864-025-11769-6

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