Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis
Abstract Background Proton beam therapy (PBT) has been gradually introduced for treating choroidal melanoma. This study systematically reviewed clinical reports to evaluate the efficacy and safety of PBT in choroidal melanoma patients. Methods This systematic review included all the primary studies...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-024-02580-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544413449289728 |
|---|---|
| author | Yuxin Miao Tingwei Zheng Qiuning Zhang Meixuan Li Qihang Lei Qin Liu Hongtao Luo Huiling Bai |
| author_facet | Yuxin Miao Tingwei Zheng Qiuning Zhang Meixuan Li Qihang Lei Qin Liu Hongtao Luo Huiling Bai |
| author_sort | Yuxin Miao |
| collection | DOAJ |
| description | Abstract Background Proton beam therapy (PBT) has been gradually introduced for treating choroidal melanoma. This study systematically reviewed clinical reports to evaluate the efficacy and safety of PBT in choroidal melanoma patients. Methods This systematic review included all the primary studies involving PBT for choroidal melanoma patients through April 2024. Four publicly accessible databases were searched, and the statistical data were analyzed using STATA 15.0. The outcomes of interest included overall survival (OS), metastasis-free survival, local control rate, and adverse reactions. Results A total of six case series involving 1059 patients with choroidal melanoma were included. The random effect model meta-analysis showed that the 2-, 3-, 5-, and 10-year OS rates of patients with choroidal melanoma treated with PBT were 97%, 92%, 73%, and 39%, respectively. The metastasis-free survival rates at 2, 3, and 5 years were 92%, 89%, and 76%, respectively, and the local control rates at 1, 3, 5, and 10 years were 98%, 92%, 94%, and 88%, respectively. Four studies reported adverse reactions. The most common adverse reactions after PBT were glaucoma, optic neuropathy, and cataracts, with incidence rates ranging from 17.9 to 27%, 12.8–64%, and 29.6–39.8%, respectively. Conclusions This meta-analysis identified PBT as a vital local treatment strategy against choroidal melanoma. Both OS and local control rates showed excellent results. However, more prospective trials can help compare the efficacy of PBT with typical therapy. |
| format | Article |
| id | doaj-art-18ac00a05c0d4555a141c4950f496ea0 |
| institution | Kabale University |
| issn | 1748-717X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj-art-18ac00a05c0d4555a141c4950f496ea02025-01-12T12:33:59ZengBMCRadiation Oncology1748-717X2025-01-0120111110.1186/s13014-024-02580-wEfficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysisYuxin Miao0Tingwei Zheng1Qiuning Zhang2Meixuan Li3Qihang Lei4Qin Liu5Hongtao Luo6Huiling Bai7The First School of Clinical Medical, Gansu University of Chinese MedicineThe First School of Clinical Medical, Gansu University of Chinese MedicineInstitute of Modern Physics, Chinese Academy of SciencesEvidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou UniversityThe First School of Clinical Medical, Gansu University of Chinese MedicineThe First School of Clinical Medical, Gansu University of Chinese MedicineGansu Provincial Hospital of TCMThe First School of Clinical Medical, Gansu University of Chinese MedicineAbstract Background Proton beam therapy (PBT) has been gradually introduced for treating choroidal melanoma. This study systematically reviewed clinical reports to evaluate the efficacy and safety of PBT in choroidal melanoma patients. Methods This systematic review included all the primary studies involving PBT for choroidal melanoma patients through April 2024. Four publicly accessible databases were searched, and the statistical data were analyzed using STATA 15.0. The outcomes of interest included overall survival (OS), metastasis-free survival, local control rate, and adverse reactions. Results A total of six case series involving 1059 patients with choroidal melanoma were included. The random effect model meta-analysis showed that the 2-, 3-, 5-, and 10-year OS rates of patients with choroidal melanoma treated with PBT were 97%, 92%, 73%, and 39%, respectively. The metastasis-free survival rates at 2, 3, and 5 years were 92%, 89%, and 76%, respectively, and the local control rates at 1, 3, 5, and 10 years were 98%, 92%, 94%, and 88%, respectively. Four studies reported adverse reactions. The most common adverse reactions after PBT were glaucoma, optic neuropathy, and cataracts, with incidence rates ranging from 17.9 to 27%, 12.8–64%, and 29.6–39.8%, respectively. Conclusions This meta-analysis identified PBT as a vital local treatment strategy against choroidal melanoma. Both OS and local control rates showed excellent results. However, more prospective trials can help compare the efficacy of PBT with typical therapy.https://doi.org/10.1186/s13014-024-02580-wProton therapyRadiotherapyChoroidal melanomaMeta-analysis |
| spellingShingle | Yuxin Miao Tingwei Zheng Qiuning Zhang Meixuan Li Qihang Lei Qin Liu Hongtao Luo Huiling Bai Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis Radiation Oncology Proton therapy Radiotherapy Choroidal melanoma Meta-analysis |
| title | Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis |
| title_full | Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis |
| title_short | Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis |
| title_sort | efficacy and safety of proton radiotherapy in treating choroidal melanoma a systematic review and meta analysis |
| topic | Proton therapy Radiotherapy Choroidal melanoma Meta-analysis |
| url | https://doi.org/10.1186/s13014-024-02580-w |
| work_keys_str_mv | AT yuxinmiao efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT tingweizheng efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT qiuningzhang efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT meixuanli efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT qihanglei efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT qinliu efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT hongtaoluo efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis AT huilingbai efficacyandsafetyofprotonradiotherapyintreatingchoroidalmelanomaasystematicreviewandmetaanalysis |