Enhancing Tumor Immunity with IL-12 and PD-1 Blockade: A Strategy for Inducing Robust Central Memory T Cell Responses in Resistant Cancer Model

Enhancing Tumor Immunity with IL-12 and PD-1 Blockade: A Strategy for Inducing Robust Central Memory T Cell Responses in Resistant Cancer Model

<b>Background:</b> Although immune checkpoint inhibitors (ICIs) have demonstrated efficacy in treating advanced cancers, their therapeutic success remains limited for many patients, with initial responders often experiencing resistance and relapse. Interleukin-12 (IL-12) is a powerful cy...

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Bibliographic Details
Main Authors: Fentian Chen, Kexin Wu, Shiqi Lin, Jinlong Cui, Xiaoqing Chen, Zhiren Zeng, Na Yuan, Mujin Fang, Xue Liu, Yuanzhi Chen, Wenxin Luo
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antibodies
Subjects:
immune checkpoint
interleukin-12
PD-1
CTLA-4
central memory T cell
Online Access:https://www.mdpi.com/2073-4468/13/4/94
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