Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV

Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV

Despite viral suppression with antiretroviral therapy (ART), people with HIV (PWH) continue to exhibit brain pathology, and ~20% of individuals develop HIV-associated neurocognitive disorders. However, the state of cellular activation in the brain of virally suppressed (VS) PWH and the impact of loc...

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Bibliographic Details
Main Authors: Sarah J. Byrnes, Janna Jamal Eddine, Jingling Zhou, Emily Chalmers, Emma Wanicek, Narin Osman, Trisha A. Jenkins, Michael Roche, Bruce J. Brew, Jacob D. Estes, Thomas A. Angelovich, Melissa J. Churchill
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
HIV
brain
neuroinflammation
reservoirs
microglia
astrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570692/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570692/full

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