Hepatopulmonary syndrome associated with long-term use of ado-trastuzumab emtansine (T-DM1) for treatment of HER2-positive metastatic breast cancer - a case report and series

Hepatopulmonary syndrome associated with long-term use of ado-trastuzumab emtansine (T-DM1) for treatment of HER2-positive metastatic breast cancer - a case report and series

BackgroundThe advent of antibody-drug conjugates (ADCs) represents a landmark advance in cancer therapy, permitting targeted delivery of a potent cytotoxic agent to tumor cells with minimal damage to surrounding cells. Although ADCs can induce sustained therapeutic responses in heavily pretreated pa...

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Bibliographic Details
Main Authors: Ciara C. O’Sullivan, Alexandra S. Higgins, Adham K. Alkurashi, Vaibhav Ahluwalia, Jodi L. Taraba, Paul M. McKie, Patrick S. Kamath, Vivek N. Iyer, Tufia C. Haddad
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Oncology
Subjects:
antibody-drug conjugates (ADCs)
ado-trastuzumab emtansine (T-DM1)
hepatotoxicity
breast cancer
portal hypertension
hepatopulmonary syndrome (HPS)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1434492/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1434492/full

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