Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study
Abstract Background Hip fracture is common and associated with high morbidity and mortality rates. Selective serotonin reuptake inhibitors (SSRIs) influence platelet hemostasis and might result in abnormal bleeding. This study aims to determine whether the use of SSRIs in older patients undergoing h...
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BMC
2024-12-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-024-05634-6 |
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| author | Héloïse Gobillot-Morisson Bastien Genet Corinne Frère Judith Cohen-Bittan Mathieu Raux Marie-Eva Rollet Anthony Meziere Jacques Boddaert Lorène Zerah Sara Thietart |
| author_facet | Héloïse Gobillot-Morisson Bastien Genet Corinne Frère Judith Cohen-Bittan Mathieu Raux Marie-Eva Rollet Anthony Meziere Jacques Boddaert Lorène Zerah Sara Thietart |
| author_sort | Héloïse Gobillot-Morisson |
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| description | Abstract Background Hip fracture is common and associated with high morbidity and mortality rates. Selective serotonin reuptake inhibitors (SSRIs) influence platelet hemostasis and might result in abnormal bleeding. This study aims to determine whether the use of SSRIs in older patients undergoing hip fracture surgery is associated with the risk of perioperative red blood cell (RBC) transfusion. Methods We conducted a retrospective observational study using prospectively collected data of patients aged 70 years and older admitted to a French geriatric perioperative ward for hip fracture between January 2012 and June 2021. The primary endpoint was the occurrence of RBC transfusion during hospitalization. Multivariate logistic regression was performed, with a sensitivity analysis according to co-prescriptions. Results Out of 1085 patients, 253 (23%) were male, mean age was 86 (± 6.2) years, and median Charlson Comorbidity Index was 7 (interquartile range [5–8]). 486 (45%) patients received perioperative RBC transfusion, with a median of 2 units (interquartile range [1–3]) transfused per patient postoperatively. After adjusting for age, sex, comorbidities, functional status, institutionalization, polypharmacy, antiplatelet therapy, fracture type, hemoglobin and albumin levels, the use of SSRIs was not associated with an increased risk of RBC transfusion (aOR 0.91, 95%CI 0.64–1.29, p = 0.59). We did not observe any association between concomitant use of SSRIs and anticoagulant or antiplatelet therapy and the risk of RBC transfusion. Conclusions Among older comorbid adults undergoing hip fracture surgery, the use of SSRIs was not associated with an increased risk of perioperative RBC transfusion. |
| format | Article |
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| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj-art-17695177051a4bc180dfc8ed28b6a8382025-01-05T12:45:27ZengBMCBMC Geriatrics1471-23182024-12-012411910.1186/s12877-024-05634-6Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort studyHéloïse Gobillot-Morisson0Bastien Genet1Corinne Frère2Judith Cohen-Bittan3Mathieu Raux4Marie-Eva Rollet5Anthony Meziere6Jacques Boddaert7Lorène Zerah8Sara Thietart9Département de Gériatrie, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-SalpêtrièreDépartement de Santé Publique, Sorbonne Université, INSERM, Institut Pierre Louis d’Épidémiologie Et de Santé Publique, AP-HP, Hôpital Pitié-SalpêtrièreDépartement d’Hématologie Biologique, Sorbonne Université, INSERM, UMRS 1166, AP-HP, Hôpital Pitié-SalpêtrièreDépartement de Gériatrie, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-SalpêtrièreDépartement d’Anesthésie Réanimation, Sorbonne Université, INSERM, UMRS 1158, AP-HP, Hôpital Pitié-SalpêtrièreDépartement de Chirurgie Orthopédique et Traumatologique, Saint-Laurent-du-Var, France, et Institut Niçois du Sport et de l’Arthrose, Institut Arnaud TzanckDépartement de Médecine Gériatrique, Université Paris Cité, AP-HP, Hôpital Corentin CeltonDépartement de Gériatrie, Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses (Cimi-Paris), AP-HP, Hôpital Pitié-SalpêtrièreDépartement de Gériatrie, Sorbonne Université, INSERM, Institut Pierre Louis d’Épidémiologie Et de Santé Publique, AP-HP, Hôpital Pitié-SalpêtrièreDépartement de Gériatrie, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-SalpêtrièreAbstract Background Hip fracture is common and associated with high morbidity and mortality rates. Selective serotonin reuptake inhibitors (SSRIs) influence platelet hemostasis and might result in abnormal bleeding. This study aims to determine whether the use of SSRIs in older patients undergoing hip fracture surgery is associated with the risk of perioperative red blood cell (RBC) transfusion. Methods We conducted a retrospective observational study using prospectively collected data of patients aged 70 years and older admitted to a French geriatric perioperative ward for hip fracture between January 2012 and June 2021. The primary endpoint was the occurrence of RBC transfusion during hospitalization. Multivariate logistic regression was performed, with a sensitivity analysis according to co-prescriptions. Results Out of 1085 patients, 253 (23%) were male, mean age was 86 (± 6.2) years, and median Charlson Comorbidity Index was 7 (interquartile range [5–8]). 486 (45%) patients received perioperative RBC transfusion, with a median of 2 units (interquartile range [1–3]) transfused per patient postoperatively. After adjusting for age, sex, comorbidities, functional status, institutionalization, polypharmacy, antiplatelet therapy, fracture type, hemoglobin and albumin levels, the use of SSRIs was not associated with an increased risk of RBC transfusion (aOR 0.91, 95%CI 0.64–1.29, p = 0.59). We did not observe any association between concomitant use of SSRIs and anticoagulant or antiplatelet therapy and the risk of RBC transfusion. Conclusions Among older comorbid adults undergoing hip fracture surgery, the use of SSRIs was not associated with an increased risk of perioperative RBC transfusion.https://doi.org/10.1186/s12877-024-05634-6Hip fractureRed blood cell transfusionSelective serotonin reuptake inhibitorsOrthogeriatric pathwayPlatelet hemostasisPerioperative |
| spellingShingle | Héloïse Gobillot-Morisson Bastien Genet Corinne Frère Judith Cohen-Bittan Mathieu Raux Marie-Eva Rollet Anthony Meziere Jacques Boddaert Lorène Zerah Sara Thietart Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study BMC Geriatrics Hip fracture Red blood cell transfusion Selective serotonin reuptake inhibitors Orthogeriatric pathway Platelet hemostasis Perioperative |
| title | Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study |
| title_full | Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study |
| title_fullStr | Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study |
| title_full_unstemmed | Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study |
| title_short | Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study |
| title_sort | association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture a cohort study |
| topic | Hip fracture Red blood cell transfusion Selective serotonin reuptake inhibitors Orthogeriatric pathway Platelet hemostasis Perioperative |
| url | https://doi.org/10.1186/s12877-024-05634-6 |
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