High-Yield Synthesis of <i>N</i><sup>4</sup>-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine via <i>N</i>-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)-6-nitroquinazolin-4-amine

High-Yield Synthesis of <i>N</i><sup>4</sup>-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine via <i>N</i>-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)-6-nitroquinazolin-4-amine

The target compound, <i>N</i><sup>4</sup>-(3-chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine, was synthesized in two steps from <i>N</i>-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine by a nucleophilic aromatic substitution, y...

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Bibliographic Details
Main Authors: Susila Thapa, Jeanne L. Bolliger
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molbank
Subjects:
quinazoline
heterocyclic chemistry
nucleophilic aromatic substitution
reduction
Online Access:https://www.mdpi.com/1422-8599/2025/1/M1958
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