SOCS1 deficiency—crossroads of autoimmunity and autoinflammation—two case reports

SOCS1 deficiency—crossroads of autoimmunity and autoinflammation—two case reports

Suppressors of cytokine signaling (SOCS) proteins play a critical role in regulating immune signaling pathways. Deficiency of SOCS1 leads to various autoimmune pathologies. We present two unrelated patients with distinct clinical manifestations. Patient 1, a 16-year-old male from Guinea, presented w...

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Bibliographic Details
Main Authors: Kajetan Trojovsky, Maximilian Seidl, Florian Babor, Stephan Ehl, Min Ae Lee-Kirsch, Michael Friedt, Hans-Juergen Laws, Nibras Naami, Prasad Thomas Oommen, Sujal Ghosh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pediatrics
Subjects:
SOCS1
SOCS1 haploinsufficiency
SOCS1 deficiency
CRMO
CNO
autoinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2024.1516017/full
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https://www.frontiersin.org/articles/10.3389/fped.2024.1516017/full

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