Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation
Objective: Immune checkpoint inhibition (ICI) has significantly advanced the field of immuno-oncology, yet not all patients benefit from this therapy. Combining ICI with other therapeutic modalities, including tumor ablation, is currently being explored as a method to enhance ICI efficacy. Mechanica...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2430333 |
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| author | Vera Mekers Mirjam de Visser Karijn Suijkerbuijk Clemens Bos Chrit Moonen Roel Deckers Gosse Adema |
| author_facet | Vera Mekers Mirjam de Visser Karijn Suijkerbuijk Clemens Bos Chrit Moonen Roel Deckers Gosse Adema |
| author_sort | Vera Mekers |
| collection | DOAJ |
| description | Objective: Immune checkpoint inhibition (ICI) has significantly advanced the field of immuno-oncology, yet not all patients benefit from this therapy. Combining ICI with other therapeutic modalities, including tumor ablation, is currently being explored as a method to enhance ICI efficacy. Mechanical High-Intensity Focused Ultrasound (M-HIFU) represents a promising tumor ablative therapy, inducing cavitation within the tumor, resulting in tumor cell destruction and the release of danger signals and tumor antigens, two key factors contributing to anti-tumor immune responses.Methods/Results: Preclinical studies on the impact of M-HIFU on the anti-tumor immune response are guiding the translational application of this technique in the clinical setting. This review provides a comprehensive overview of the current understanding of the effects of M-HIFU on the immune system. We report on the effect of M-HIFU on soluble immune modulators and immune cells in different preclinical models, and potential contributions to the anti-tumor immune response. We discuss clinical studies applying M-HIFU and studies that have combined ICI with other ablative therapies to draw parallels to clinical implementation of M-HIFU. Further, we will highlight essential questions that should be addressed in future clinical trials exploring the combination of M-HIFU and ICI in the clinical setting.Conclusion: Overall, this review offers guidance for the clinical implementation of combining M-HIFU with ICI and highlights key questions that remain to be addressed in first clinical studies. |
| format | Article |
| id | doaj-art-16998a872185475b8e5305ec39286433 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-16998a872185475b8e5305ec392864332025-01-03T09:30:28ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2430333Mechanical HIFU and immune checkpoint inhibition: toward clinical implementationVera Mekers0Mirjam de Visser1Karijn Suijkerbuijk2Clemens Bos3Chrit Moonen4Roel Deckers5Gosse Adema6Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, NetherlandsDivision of Imaging & Oncology, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht, NetherlandsDivision of Imaging & Oncology, University Medical Center Utrecht, Utrecht, NetherlandsDivision of Imaging & Oncology, University Medical Center Utrecht, Utrecht, NetherlandsDivision of Imaging & Oncology, University Medical Center Utrecht, Utrecht, NetherlandsRadiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, NetherlandsObjective: Immune checkpoint inhibition (ICI) has significantly advanced the field of immuno-oncology, yet not all patients benefit from this therapy. Combining ICI with other therapeutic modalities, including tumor ablation, is currently being explored as a method to enhance ICI efficacy. Mechanical High-Intensity Focused Ultrasound (M-HIFU) represents a promising tumor ablative therapy, inducing cavitation within the tumor, resulting in tumor cell destruction and the release of danger signals and tumor antigens, two key factors contributing to anti-tumor immune responses.Methods/Results: Preclinical studies on the impact of M-HIFU on the anti-tumor immune response are guiding the translational application of this technique in the clinical setting. This review provides a comprehensive overview of the current understanding of the effects of M-HIFU on the immune system. We report on the effect of M-HIFU on soluble immune modulators and immune cells in different preclinical models, and potential contributions to the anti-tumor immune response. We discuss clinical studies applying M-HIFU and studies that have combined ICI with other ablative therapies to draw parallels to clinical implementation of M-HIFU. Further, we will highlight essential questions that should be addressed in future clinical trials exploring the combination of M-HIFU and ICI in the clinical setting.Conclusion: Overall, this review offers guidance for the clinical implementation of combining M-HIFU with ICI and highlights key questions that remain to be addressed in first clinical studies.https://www.tandfonline.com/doi/10.1080/02656736.2024.2430333Mechanical HIFUhigh-intensity focused ultrasoundhistotripsyimmune checkpoint inhibitionclinical implementation |
| spellingShingle | Vera Mekers Mirjam de Visser Karijn Suijkerbuijk Clemens Bos Chrit Moonen Roel Deckers Gosse Adema Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation International Journal of Hyperthermia Mechanical HIFU high-intensity focused ultrasound histotripsy immune checkpoint inhibition clinical implementation |
| title | Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation |
| title_full | Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation |
| title_fullStr | Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation |
| title_full_unstemmed | Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation |
| title_short | Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation |
| title_sort | mechanical hifu and immune checkpoint inhibition toward clinical implementation |
| topic | Mechanical HIFU high-intensity focused ultrasound histotripsy immune checkpoint inhibition clinical implementation |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2430333 |
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