A versatile silica nanoparticle platform for induction of T cell responses – applied for therapeutic vaccination against HPV16 E6/E7-positive tumors in MHC-humanized mice

A versatile silica nanoparticle platform for induction of T cell responses – applied for therapeutic vaccination against HPV16 E6/E7-positive tumors in MHC-humanized mice

Therapeutic vaccines represent a promising treatment option for (pre)cancerous lesions, such as human papillomavirus-induced malignancies. They act via administration of tumor-specific antigens, leading to induction of antigen-specific cytotoxic T cell responses. However, vaccination efficiency is o...

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Bibliographic Details
Main Authors: Sebastian Kruse, Lia T. Fricke, Samantha Zottnick, Ann-Katrin Schlosser, Agnieszka K. Grabowska, Eva Feidt, Philipp Uhl, Ellen Junglas, Jonas D. Förster, Josephine Blersch, Philip Denner, Manina Günter, Stella E. Autenrieth, Eugenio Fava, Walter Mier, Armin Kübelbeck, Angelika B. Riemer
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Amorphous silica nanoparticles
cervical cancer
therapeutic vaccination
MHC-humanized mouse model
A2.DR1
human papillomavirus (HPV)
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2548002
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2548002

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