miR-130b-5p下调胰岛素样生长因子-1抑制人绒毛膜滋养层细胞迁移及侵袭的作用及机制
目的探究微小RNA 130b-5p（miR-130b-5p）靶向胰岛素样生长因子-1（<italic>IGF-1</italic>）对人绒毛膜滋养层细胞（HTR8/SVneo）迁移及侵袭的影响。方法将HTR8/SVneo细胞分为对照组、miR-NC组、miR-130b-5pmimics组、miR-130b-5pmimics+pcDNA3.1组和miR-130b-5pmimics+pcDNA3.1-IGF-1组，双荧光素酶报告基因检测miR-130b-5p和IGF-1的靶向关系；采用实时荧光定量PCR检测HTR8/SVneo细胞样本中miR-130b-5p及<ita...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2022-07-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Subjects: | |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0404/ |
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