Simian Immunodeficiency Virus-Based Virus-like Particles Are an Efficient Tool to Induce Persistent Anti-SARS-CoV-2 Spike Neutralizing Antibodies and Specific T Cells in Mice

Simian Immunodeficiency Virus-Based Virus-like Particles Are an Efficient Tool to Induce Persistent Anti-SARS-CoV-2 Spike Neutralizing Antibodies and Specific T Cells in Mice

<b>Background/Objectives:</b> Virus-like particles (VLPs) represent an attractive platform for delivering vaccine formulations, combining a high biosafety profile with a potent immune-stimulatory ability. VLPs are non-infectious, non-replicating, self-assembling nanostructures that can b...

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Main Authors: Alessandra Gallinaro, Chiara Falce, Maria Franca Pirillo, Martina Borghi, Felicia Grasso, Andrea Canitano, Serena Cecchetti, Marco Baratella, Zuleika Michelini, Sabrina Mariotti, Maria Vincenza Chiantore, Iole Farina, Antonio Di Virgilio, Antonella Tinari, Gabriella Scarlatti, Donatella Negri, Andrea Cara
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Vaccines
Subjects:
virus-like particles
SARS-CoV-2
neutralizing antibodies
vaccine
spike
GAG
Online Access:https://www.mdpi.com/2076-393X/13/3/216
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