Entamoeba histolytica “mutator” strain with a high rate of genetic mutations assists the elucidation of drug resistance mechanisms

Entamoeba histolytica “mutator” strain with a high rate of genetic mutations assists the elucidation of drug resistance mechanisms

ABSTRACT In drug discovery, target identification and elucidation of resistance mechanisms are essential. The pathogen strains resistant to a compound of interest are useful for these purposes. As the generation of drug-resistant strains is time-consuming and often burdensome, we generated the Entam...

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Main Authors: Yumiko Saito-Nakano, Shinji Izumiyama, Makoto Hirai, Tetsuro Kawano-Sugaya, Ghulam Jeelani, Sanjib K. Sardar, Sandipan Ganguly, Tomoyoshi Nozaki
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Entamoeba histolytica
mutator
miltefosine
drug resistance
error-prone DNA polymerase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01210-25
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https://journals.asm.org/doi/10.1128/spectrum.01210-25

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