Functional Characterization of the Canine Heme-Regulated eIF2α Kinase: Regulation of Protein Synthesis

Functional Characterization of the Canine Heme-Regulated eIF2α Kinase: Regulation of Protein Synthesis

The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2α (eIF2α) thereby inhibiting protein translation. The importance of HRI in regulating hemoglobin synthesis in erythroid cells makes it an attractive molecular target in need of...

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Bibliographic Details
Main Authors: Kimon C. Kanelakis, Jayashree Pyati, Pamela C. Wagaman, Jui Chang Chuang, Young Yang, Nigel P. Shankley
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2009/251915
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