Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer

Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer

Abstract In epithelial ovarian cancer (EOC), platinum resistance, potentially mediated by cancer stem cells (CSCs), often leads to relapse and treatment failure. Here, the role of spindle pole body component 25 (SPC25) as a key determinant promoting stemness and platinum resistance in EOC cells, wit...

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Main Authors: Xingyu Jiang, Muwen Yang, Weijing Zhang, Dongni Shi, Yue Li, Lixin He, Shumei Huang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Yibing Pan, Pinwei Deng, Rui Wang, Ying Ouyang, Xiangfu Chen, Jun Li, Zheng Li, Hequn Zou, Yanna Zhang, Libing Song
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cancer stem cell
cell‐penetrating peptide
epithelial ovarian cancer
phosphorylation
platinum resistance
protein‐protein interaction
Online Access:https://doi.org/10.1002/advs.202406688
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https://doi.org/10.1002/advs.202406688

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