Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics.

Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics.

Pluripotent stem cells retain the developmental timing of their species of origin in vitro, an observation that suggests the existence of a cell-intrinsic developmental clock, yet the nature and machinery of the clock remain a mystery. We hypothesize that one possible component may lie in species-sp...

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Main Authors: Christopher Barry, Matthew T Schmitz, Cara Argus, Jennifer M Bolin, Mitchell D Probasco, Ning Leng, Bret M Duffin, John Steill, Scott Swanson, Brian E McIntosh, Ron Stewart, Christina Kendziorski, James A Thomson, Rhonda Bacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-12-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007543&type=printable
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https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007543&type=printable

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