Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer

Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer

Abstract The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity. Through a high-throughput drug repositioning screen, we identify the antibiotic Nifuroxazide (NIF) as a...

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Main Authors: Celia D. Rouault, Lucile Bansard, Elena Martínez-Balsalobre, Caroline Bonnet, Julien Wicinski, Shuheng Lin, Ludovic Colombeau, Sylvain Debieu, Guillaume Pinna, Marie Vandamme, Margot Machu, Olivier Rosnet, Véronique Chevrier, Cornel Popovici, Hagay Sobol, Rémy Castellano, Eddy Pasquier, Geraldine Guasch, Raphaël Rodriguez, Julie Pannequin, Jean-Marc Pascussi, Christophe Lachaud, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57476-4
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https://doi.org/10.1038/s41467-025-57476-4

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