Physicochemical and Biological Modifications in Mesenchymal Stem Cells-Derived Conditioned Media Under Hypoxic Preconditioning: Impact on Oxidative Stress and Nanoparticle Stability

Physicochemical and Biological Modifications in Mesenchymal Stem Cells-Derived Conditioned Media Under Hypoxic Preconditioning: Impact on Oxidative Stress and Nanoparticle Stability

Hypoxic preconditioning (HP) is a promising approach to enhance the therapeutic efficacy of mesenchymal stem cells (MSCs) by modulating their oxidative stress response, metabolic activity, and secretome composition. Conditioned media (CM) obtained from MSCs cultured under hypoxia contains bioactive...

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Bibliographic Details
Main Authors: Gülsemin Çiçek, Fatma Öz Bağcı, Mehmet Filizfidan, Selçuk Duman, Tahsin Murad Aktan
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Life
Subjects:
mesenchymal stem cells
hypoxic preconditioning
oxidative stress
conditioned media
nanoparticle stability
HIF-1α
Online Access:https://www.mdpi.com/2075-1729/15/5/702
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