Identification of the Selenoprotein S Positive UGA Recoding (SPUR) element and its position-dependent activity

Identification of the Selenoprotein S Positive UGA Recoding (SPUR) element and its position-dependent activity

Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3′ UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS)...

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Bibliographic Details
Main Authors: Eric M. Cockman, Vivek Narayan, Belinda Willard, Sumangala P. Shetty, Paul R. Copeland, Donna M. Driscoll
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:RNA Biology
Subjects:
Selenoproteins
Selenoprotein S
selenocysteine
mRNA translation
3′ untranslated region
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2019.1653681
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https://www.tandfonline.com/doi/10.1080/15476286.2019.1653681

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