Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and management model for the prevention of vertical transmission of HIV in Malawi: The PAC-Man trial protocol

Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and management model for the prevention of vertical transmission of HIV in Malawi: The PAC-Man trial protocol

Abstract Background In Malawi and elsewhere in Africa, many children living with HIV are unaware of their status, often because of missed services for the prevention of vertical transmission of HIV (PVTH). Pregnant and breastfeeding women (PBFW) living with HIV frequently go without viral load (VL)...

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Main Authors: Michael E. Herce, Caitlin Cassidy, Alexandra Munson, Jessie K. Edwards, Sarah E. Rutstein, Mitch Matoga, Chimwemwe Kumwenda, Katherine R. Simon, Joep J. van Oosterhout, Carrie M. Cox, Funny Kamanga, Wiza Kumwenda, Sam Phiri, Ethel Rambiki, Agness Thawani, Jacqueline Huwa, Bridget Malewezi, Tisu Mvalo, Agatha Bula, Lameck Chinula, Irving Hoffman, Madeleine A. Squibb, Rose K. Nyirenda, Friday Saidi, Mina C. Hosseinipour, Maganizo B. Chagomerana
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Implementation Science Communications
Subjects:
HIV/AIDS
Stepped-wedge trial
Hybrid effectiveness-implementation trial
Malawi
Early infant diagnosis
Prevention of vertical transmission of HIV
Online Access:https://doi.org/10.1186/s43058-025-00762-5
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https://doi.org/10.1186/s43058-025-00762-5

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