The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity

The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity

Rotenone is a natural compound from plants. It is widely used in pesticides because of highly toxic to insects and fish. However, lots of research has reported that rotenone has neurotoxic effects in humans. It is confirmed there is a correlation between rotenone exposure and Parkinson’s disease (PD...

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Bibliographic Details
Main Authors: Yan Sai, Wei Ge, Li Zhong, Qifu Zhang, Jingsong Xiao, Yaohui Shan, Wenqi Ye, Haoyin Liu, Shulin Liu, Feng Ye, Xiaogang Wang, He Tang, Yuanpeng Zhao, Guorong Dan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Toxicology
Subjects:
Rotenone
Neurotoxicity
Gut microbiota
Metabolomics
Inflammatory response
Nicotinate and nicotinamide metabolic pathways
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000653
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