Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia

Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia

Abstract Background The human body is highly dependent on adequate oxygenation of the cellular space for physiologic homeostasis mediation. The insufficient oxygenation of the cellular space leads to hypoxia. Hypobaric hypoxia (HH) is the reduction in oxygen partial pressure and atmospheric pressure...

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Main Authors: Prosperl Ivette Wowui, Richard Mprah, Marie Louise Ndzie Noah, Joseph Adu-Amankwaah, Anastasia Wemaaatu Lamawura Kanoseh, Li Tao, Diana Chulu, Simon Kumah Yalley, Saffia Shaheen, Hong Sun
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Hypobaric hypoxia
Estrogen
Macrophage migration inhibitory factor
Hypoxia-inducible factor-1α
G-protein-coupled estrogen receptor
Myocardial inflammation
Online Access:https://doi.org/10.1186/s10020-025-01144-2
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https://doi.org/10.1186/s10020-025-01144-2

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