Exosome-mediated microglia-astrocyte interactions drive neuroinflammation in Parkinson's disease with Peli1 as a potential therapeutic target

Exosome-mediated microglia-astrocyte interactions drive neuroinflammation in Parkinson's disease with Peli1 as a potential therapeutic target

Neuroinflammation is a key feature of Parkinson's disease (PD), characterized by activated microglia and the conversion of astrocytes into the neurotoxic phenotype, exacerbating the neuroinflammation. In PD, microglia critically drive neurotoxic reactive astrocytes (A1, A1-like, or neuroinflamm...

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Bibliographic Details
Main Authors: Min Guo, Ao Guan, Minjie Zhang, Haiqing Li, Weishi Liu, Bangsheng Wu, Weiwei Shen, Tongyao You, Suzhen Liang, Qiang Dong, Jintai Yu, Yanxin Zhao, Mei Cui
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Pharmacological Research
Subjects:
Parkinson’s disease
Microglia
Exosome
Peli1
Neurotoxic reactive astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003330
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