Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema

Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema

Abstract Background Alveolar type II (ATII) cells have a stem cell potential in the adult lung and repair the epithelium after injury induced by harmful factors. Their damage contributes to emphysema development, characterized by alveolar wall destruction. Cigarette smoke is the main risk factor for...

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Bibliographic Details
Main Authors: Hannah Simborio, Hassan Hayek, Beata Kosmider, John W. Elrod, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Karim Bahmed
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
COPD
ATII cells
Mitochondrial respiration
Cell cycle
Apoptosis
Double strand breaks
Online Access:https://doi.org/10.1186/s12964-024-01896-0
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https://doi.org/10.1186/s12964-024-01896-0

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