Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge
Plasmablastic lymphoma is a rare type of highly aggressive B-cell non-Hodgkin lymphoma that usually occurs in immunocompromised patients and involves chiefly extra-nodal sites such as the oral cavity, jaw, gastrointestinal tract, soft tissue, bone, and skin. People above the age of 50 years are more...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_944_22 |
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| author | Anurag Singh Vinita Agrawal Alka Singh |
| author_facet | Anurag Singh Vinita Agrawal Alka Singh |
| author_sort | Anurag Singh |
| collection | DOAJ |
| description | Plasmablastic lymphoma is a rare type of highly aggressive B-cell non-Hodgkin lymphoma that usually occurs in immunocompromised patients and involves chiefly extra-nodal sites such as the oral cavity, jaw, gastrointestinal tract, soft tissue, bone, and skin. People above the age of 50 years are more commonly affected, with male predominance having a survival rate of 8 to 15 months. Here, we describe the case of a 48-year-old man who had an isolated plasmablastic lymphoma of the right sphenoid bone without any immunodeficiency. Plasmablastic lymphoma in immunocompetent patients at rare sites is a diagnostic challenge for both clinicians and pathologists because of vague clinical and histomorphology findings. This rare case report reemphasizes the utility of complete assimilation of clinical, histopathological, and immunohistochemical findings in such rare cases. |
| format | Article |
| id | doaj-art-12e04b5203ee4e83a833f4815d99e792 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-12e04b5203ee4e83a833f4815d99e7922025-01-10T10:26:51ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-12-0167489389510.4103/ijpm.ijpm_944_22Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challengeAnurag SinghVinita AgrawalAlka SinghPlasmablastic lymphoma is a rare type of highly aggressive B-cell non-Hodgkin lymphoma that usually occurs in immunocompromised patients and involves chiefly extra-nodal sites such as the oral cavity, jaw, gastrointestinal tract, soft tissue, bone, and skin. People above the age of 50 years are more commonly affected, with male predominance having a survival rate of 8 to 15 months. Here, we describe the case of a 48-year-old man who had an isolated plasmablastic lymphoma of the right sphenoid bone without any immunodeficiency. Plasmablastic lymphoma in immunocompetent patients at rare sites is a diagnostic challenge for both clinicians and pathologists because of vague clinical and histomorphology findings. This rare case report reemphasizes the utility of complete assimilation of clinical, histopathological, and immunohistochemical findings in such rare cases.https://journals.lww.com/10.4103/ijpm.ijpm_944_22histomorphologyimmunocompetentimmunohistochemistrynon-hodgkin lymphomaplasmablastic lymphoma |
| spellingShingle | Anurag Singh Vinita Agrawal Alka Singh Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge Indian Journal of Pathology and Microbiology histomorphology immunocompetent immunohistochemistry non-hodgkin lymphoma plasmablastic lymphoma |
| title | Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge |
| title_full | Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge |
| title_fullStr | Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge |
| title_full_unstemmed | Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge |
| title_short | Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge |
| title_sort | plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient a diagnostic challenge |
| topic | histomorphology immunocompetent immunohistochemistry non-hodgkin lymphoma plasmablastic lymphoma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_944_22 |
| work_keys_str_mv | AT anuragsingh plasmablasticlymphomaofthesphenoidboneinanimmunocompetentpatientadiagnosticchallenge AT vinitaagrawal plasmablasticlymphomaofthesphenoidboneinanimmunocompetentpatientadiagnosticchallenge AT alkasingh plasmablasticlymphomaofthesphenoidboneinanimmunocompetentpatientadiagnosticchallenge |