Novel Chlorin with a HYNIC: Synthesis, <sup>99m</sup>Tc-Radiolabeling, and Initial Preclinical Evaluation

Novel Chlorin with a HYNIC: Synthesis, <sup>99m</sup>Tc-Radiolabeling, and Initial Preclinical Evaluation

The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, <sup>99m</sup>Tc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective <sup>...

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Main Authors: Alexander Popov, Nikita Suvorov, Mariia Larkina, Evgenii Plotnikov, Ruslan Varvashenya, Vitalina Bodenko, Gleb Yanovich, Petr Ostroverkhov, Maxim Usachev, Elena Filonenko, Mikhail Belousov, Mikhail Grin
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
technetium-99m
chlorin
radiopharmaceuticals
HYNIC
cancer
Online Access:https://www.mdpi.com/1420-3049/30/1/117
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Summary:The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, <sup>99m</sup>Tc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective <sup>99m</sup>Tc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with <sup>99m</sup>Tc. In this work, the conjugate of natural chlorin and HYNIC was obtained, and preliminary preclinical studies were carried out on its radiocomplex with <sup>99m</sup>Tc.
ISSN:1420-3049

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