Intratumor microbiome-derived butyrate enhances progesterone sensitivity by inducing ferroptosis in endometrial cancer

Endometrial cancer (EC) is increasingly affecting younger women, and progesterone therapy remains the cornerstone of fertility-preserving treatment (FPT). However, progesterone resistance presents a major clinical challenge. While the tumor microbiome and its metabolites have been implicated in vari...

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Bibliographic Details
Main Authors: Xingchen Li, Yiqin Wang, Yuman Wu, Jingyuan Wang, Yue Qi, Xinyi Bi, Jianliu Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Pharmacological Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003275
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