Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors

Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors

Abstract Cancer cells acquire the ability to reprogram their phenotype in response to targeted therapies, yet the transition from dormancy to proliferation in drug-resistant cancers remains poorly understood. In prostate cancer, we utilized high-plasticity mouse models and enzalutamide-resistant (EN...

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Bibliographic Details
Main Authors: Wenbin Chen, Yiyou Mao, YiYuan Zhan, Wenfeng Li, Jun Wu, Xiangming Mao, Bin Xu, Fangpeng Shu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Prostate cancer
NR2F1
Exosomes
Phenotypic transition
Treatment-resistant
Online Access:https://doi.org/10.1186/s12951-024-03025-y
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https://doi.org/10.1186/s12951-024-03025-y

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