Synthesis, antioxidant, antimicrobial activities and molecular modeling analysis of some 5-Nitro-N-phenyl-3-(phenylamino)-1H-indazole-1-carboxamide derivatives: Docking, SAR, toxicity and molecular dynamics analysis

Synthesis, antioxidant, antimicrobial activities and molecular modeling analysis of some 5-Nitro-N-phenyl-3-(phenylamino)-1H-indazole-1-carboxamide derivatives: Docking, SAR, toxicity and molecular dynamics analysis

This study reports the synthesis and characterization of a novel series of 5-nitro-N-phenyl-3-(phenylamino)-1H-indazole-1-carboxamide derivatives (5a-5v) obtained through the reaction of 3-chloro-5-nitro-N-phenyl-1H-indazole-1-carboxamide (4) with diverse aniline derivatives in isopropanol. The comp...

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Bibliographic Details
Main Authors: Mithlesh Yadav, Suraj N. Mali, Bharti Sharma, Haya Yasin, Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Archana Kapoor
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Chemical Physics Impact
Subjects:
5-Nitroindazole
Antimicrobial activity
Antioxidant activity
Molecular docking studies
Molecular dynamics simulation study
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022424002494
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